Mevopur™ Healthcare Bio-based Polymer Solutions for Medical Devices and Pharmaceutical Packaging Manufacturers of medical devices and pharmaceutical packaging are increasingly faced with the challenge of integrating sustainability into the design of their products. KEY CHARACTERISTICS • Available for polyethylene, polypropylene, ABS, polycarbonate and styrenics • Bio-content of resin carrier varies from 70% to 100% depending on polymer—calculated to ASTM D6866 standard • Manufactured at four ISO 13485 certified sites, providing global consistency and security of supply • Documented change control beyond CAS number, reducing risk of change • Drop-in solutions that can be processed like fossil-based grades on common injection molding and extrusion machines • Can be provided as ready-to-use pre-colored or additive formulation REGULATORY SUPPORT • Raw materials tested to: - ISO 10993-1 - USP and (incl. class VI) - European Pharmacopeia, monograph 3.1.3/ 3.1.5 (polyolefin packaging materials) - USP (polyethylene) - Elemental impurities as per ICH Q3D • Registered Drug Master File (Type III) and/or Device Master File • Food contact according to US FDA and APPLICATION BULLETIN Sustainability Spotlight Bio-polymers Healthcare use limitations apply—see below. It is the responsibility of the medical device manufacturer and the person placing the medical device on the market to ensure compliance of the medical device with all applicable laws and regulations, including the suitability of all raw materials and components used for its manufacture.

The nucleating agents also foster constant process settings throughout part manufacturing with a higher crystallization temperature for improved crystallization speed. REGULATORY SUPPORT • Drug delivery devices • Pharmaceutical packaging • Medical equipment KEY CHARACTERISTICS • Manufactured at four ISO 13485 certified sites, providing global consistency and increased security of supply • Documented change control beyond CAS number level, reducing the risk of change • Allows crystallization in semi-crystalline polymers to begin faster and complete earlier REGULATORY SUPPORT • Raw materials tested to: - ISO 10993-1 and USP biological evaluation - European Pharmacopeia 3.1.3/3.1.5 (polyolefin) - USP (polyethylene) - ICH Q3D elemental impurities • Registered Drug Master File (Type III) and/or Device Master File • Food contact established with FDA/EU* APPLICATION BULLETIN * FDA/EU compliance information available upon request Healthcare use limitations apply—see below. It is the responsibility of the medical device manufacturer and the person placing the medical device on the market to ensure compliance of the medical device with all applicable laws and regulations, including the suitability of all raw materials and components used for its manufacture.

Cesa™ Light Diffusion Additives enable manufacturers to develop consumer-pleasing automotive lighting systems that also meet OEM’s demands for manufacturability and cost management. Our expertise is in understanding a designer’s idea and developing the appropriate formulation to turn it into a manufacturing reality. Information we may require includes: • Which material will be used to manufacture the lens?

ECCOH™ Specialty Solutions Helping Cable Manufacturers Meet CPR Standards PRODUCT BULLETIN ECCOH™ Low Smoke and Fume Non-Halogen (LSFOH) formulations offer a range of non- halogen, flame retardant solutions that enable manufacturers to meet the Construction Products Regulation (CPR) standards set out by the harmonized European Standard, EN13501. SELECTING THE RIGHT ECCOH SOLUTION Avient provides additional technical services to help cable manufacturers find the right CPR compliant cable solutions. The cable design, other materials used in the cable, and the cable manufacturing process can all influence CPR test results.

ECCOH™ Specialty Solutions Helping Cable Manufacturers Meet CPR Standards PRODUCT BULLETIN ECCOH™ Low Smoke and Fume Non-Halogen (LSFOH) formulations offer a range of non- halogen, flame retardant solutions that enable manufacturers to meet the Construction Products Regulation (CPR) standards set out by the harmonized European Standard, EN13501. SELECTING THE RIGHT ECCOH SOLUTION Avient provides additional technical services to help cable manufacturers find the right CPR compliant cable solutions. The cable design, other materials used in the cable, and the cable manufacturing process can all influence CPR test results.

Validity Avient Switzerland GmbH Hauptstrasse 30 4127 Birsfelden Switzerland Design and manufacture of colour and additive concentrates and specialty compounds for the Healthcare and Medical device market. Ltd. 30, Hsing Pang Road 33068 Taoyuan Taiwan Design and manufacture of colour and additive concentrates and specialty compounds for the Healthcare and Medical device market. Lewiston, ME, 04240 United States of America Design and manufacture of colour and additive concentrates and specialty compounds for the Healthcare and Medical device market.

These sweeping trends have applied intense pressure on manufacturers to produce greater quantities of products in shorter periods of time. Manufacturing steps for vulcanized rubber— pre-mixing the formulation, subsequent mixing on a two-roll mill, parts molding and secondary operations, including washing off unreacted surplus materials—present manufacturers with a costly, protracted and outdated process. Notable advantages include streamlined manufacturing, resealing performance and coring resistance.

Park, Pudong, Shanghai China, 201203 and the sites as mentioned in the appendix accompanying this certificate has been found to conform to the Quality Management System standard: GB/T 19001-2016/ISO 9001:2015 This certificate is valid for the following scope: Design and Manufacture of Masterbatch Certificate No: 7071-1998-AQ-RGC-RvA Place and date: Shanghai, 19 March, 2021 Lack of fulfilment of conditions as set out in the Certification Agreement may render this Certificate invalid. TEL:+31(0)102922689. www.dnvgl.com/assurance Page 2 of 2 Appendix to Certificate PolyOne-Shanghai, China Locations included in the certification are as follows: Site Name Site Address Site Scope PolyOne Polymer (Tianjin) Company Limited No.28#C, Jin Bin Hi-Tech Industrial Park, 156 Nan Hai Road, Tianjin Economic-Technological, Tianjin, China, 300457 Manufacture of Masterbatch PolyOne-Shanghai, China No. 88, Guo Shou Jing Road, Z. Park, Pudong, Shanghai, China, 201203 Design and Manufacture of Masterbatch

Park, China (Shanghai) Pilot Free Trade Zone, Shanghai, China 201203 and the sites as mentioned in the appendix accompanying this certificate has been found to conform to the Quality Management System standard: GB/T 19001-2016 / ISO 9001:2015 This certificate is valid for the following scope: Design and Manufacture of Colour and Additive Concentrates http://www.dnv.com/assurance Certificate no.: 7071-1998-AQ-RGC-RvA Place and date: Shanghai, 20 March 2024 Lack of fulfilment of conditions as set out in the Certification Agreement may render this Certificate invalid. ACCREDITED UNIT: DNV Business Assurance B.V., Zwolseweg 1, 2994 LB, Barendrecht, Netherlands - TEL: +31(0)102922689. www.dnv.com/assurance Page 2 of 2 Appendix to Certificate PolyOne-Shanghai, China Locations included in the certification are as follows: Site Name Site Address Site Scope PolyOne Polymer (Tianjin) Company Limited No. 28#C, Jin Bin Hi-Tech Industrial Park, No. 156, Nan Hai Road, Tianjin Economic- Technological Development Area, Tianjin, China 300457 Manufacture of Colour and Additive Concentrates PolyOne-Shanghai, China No. 88, Guo Shou Jing Road, Z. Park, China (Shanghai) Pilot Free Trade Zone, Shanghai, China 201203 Design and Manufacture of Colour and Additive Concentrates http://www.dnv.com/assurance

L A B O R ATO RY E Q U I P M E N T M A N U FA C T U R E R P C R W E L L P L A T E S • Very high level of TiO2 to prevent “cross-talk” between the wells during the qPCR fluorescence testing procedure • Minimized background phosphorescence caused by agglomeration of TiO2 and/or oxidized (stressed) polystyrene • Preservation of polystyrene grade properties • Change control of formulation and manufacturing process • Robust product quality from batch to batch • Developed optimally dispersed, ready-to-use white formulation that maintains adequate signal transmission, as well as minimizing “cross-talk” and background phosphorescence • Optimized the use of general purpose polystyrene (GPPS) for a good balance between melt flow and other physical properties, such as stiffness • Provided comprehensive change control of raw materials and formulation, with a robust manufacturing process and quality control under a third party ISO 13485:2016 certified QMS Mevopur Healthcare Colorants and Formulations – pre-colored solution WHY AVIENT? https://www.avient.com/products/polymer-colorants/healthcare-colorants/mevopur-healthcare-colorants-and-formulations Slide 1: laboratory equipment manufacturer