Letter of Authority (LoA) for our Drug Master File (DMF) and Device Master File (MAF). Disclosure of ingredients for purpose of regulatory filings (under specific confidentiality agreements).

Letter of Authority (LoA) for our Drug Master File (DMF) and Device Master File (MAF). Disclosure of ingredients for purpose of regulatory filings (under specific confidentiality agreements).

Adjusted EPS attributable to PolyOne common shareholders is calculated as follows: 2009* 2010* 2011* 2012* 2013* 2014* 2015* 2016 2017 Net income from continuing operations attributable to PolyOne common shareholders $ 106.7 $ 152.5 $ 153.4 $ 53.3 $ 94.0 $ 78.0 $ 144.6 $ 166.4 $ 173.5 Joint venture equity earnings, after tax (19.0) (14.7) (3.7) — — — — — — Special items, before tax(1) (48.7) 24.2 (48.1) 55.1 46.3 164.2 87.6 23.8 32.9 Special items, tax adjustments(1) (27.2) (96.7) (24.7) (18.9) (13.7) (73.7) (58.7) (15.9) (24.8) Adjusted net income from continuing operations attributable to PolyOne common shareholders $ 11.8 $ 65.3 $ 76.9 $ 89.5 $ 126.6 $ 168.5 $ 173.5 $ 174.3 $ 181.6 Diluted shares 93.4 96.0 94.3 89.8 96.5 93.5 88.7 84.6 82.1 Adjusted EPS attributable to PolyOne common shareholders $ 0.13 $ 0.68 $ 0.82 $ 1.00 $ 1.31 $ 1.80 $ 1.96 $ 2.06 $ 2.21 * Historical results are shown as presented in prior filings and have not been updated to reflect subsequent changes in accounting principle, discontinued operations or the related resegmentation. (1) Special items include charges related to specific strategic initiatives or financial restructuring such as: consolidation of operations; debt extinguishment costs; costs incurred directly in relation to acquisitions or divestitures; employee separation costs resulting from personnel reduction programs, plant realignment costs, executive separation agreements; asset impairments; mark-to-market adjustments associated with actuarial gains and losses on pension and other post-retirement benefit plans; environmental remediation costs, fines, penalties and related insurance recoveries related to facilities no longer owned or closed in prior years; gains and losses on the divestiture of operating businesses, joint ventures and equity investments; gains and losses on facility or property sales or disposals; results of litigation, fines or penalties, where such litigation (or action relating to the fines or penalties) arose prior to the commencement of the performance period; one-time, non-recurring items; the effect of changes in accounting principles or other such laws or provisions affecting reported results and tax adjustments. Tax adjustments include the net tax (expense) benefit from one-time income tax items, the set-up or reversal of uncertain tax position reserves and deferred income tax valuation allowance adjustments. 2 Adjusted EBITDA and net debt to adjusted EBITDA is calculated as follows: (In millions) Year Ended December 31, 2017 Income from continuing operations, before income taxes $ 212.3 Interest expense, net 60.8 Depreciation and amortization 82.8 Special items impact on income from continuing operations, before income taxes(1) 32.9 Adjusted EBITDA $ 388.8 Senior secured revolving credit facility $ 56.5 Senior secured term loan due 2022 637.5 Total Secured Debt 694.0 Less: Cash and cash equivalents (243.6) Net Secured Debt $ 450.4 Short-term and current portion of long-term debt $ 32.6 Long-term debt 1,290.9 Total Debt 1,323.5 Less: Cash and cash equivalents (243.6) Net Debt $ 1,079.9 Total Secured Debt / Adjusted EBITDA 1.8 Net Secured Debt / Adjusted EBITDA 1.2 Total Debt / Adjusted EBITDA 3.4 Net Debt / Adjusted EBITDA 2.8 (1) Special items include charges related to specific strategic initiatives or financial restructuring such as: consolidation of operations; debt extinguishment costs; costs incurred directly in relation to acquisitions or divestitures; employee separation costs resulting from personnel reduction programs, plant realignment costs, executive separation agreements; asset impairments; mark-to-market adjustments associated with actuarial gains and losses on pension and other post-retirement benefit plans; environmental remediation costs, fines, penalties and related insurance recoveries related to facilities no longer owned or closed in prior years; gains and losses on the divestiture of operating businesses, joint ventures and equity investments; gains and losses on facility or property sales or disposals; results of litigation, fines or penalties, where such litigation (or action relating to the fines or penalties) arose prior to the commencement of the performance period; one-time, non-recurring items; the effect of changes in accounting principles or other such laws or provisions affecting reported results and tax adjustments. Tax adjustments include the net tax expense/benefit from one-time income tax items, the set-up or reversal of uncertain tax position reserves and deferred income tax valuation allowance adjustments.

We support your Device Master File submission for healthcare materials by developing and maintaining U.S. FDA Drug Master Files and Medical Application Files. 

We support your Device Master File submission for healthcare materials by developing and maintaining U.S. FDA Drug Master Files and Medical Application Files. 

We support your Device Master File submission for healthcare materials by developing and maintaining U.S. FDA Drug Master Files and Medical Application Files. 

We support your Device Master File submission for healthcare materials by developing and maintaining U.S. FDA Drug Master Files and Medical Application Files. 

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Ripple holds a Bachelor of Science in Chemistry from Texas A&M University and an executive MBA from the University of Michigan’s Ross School of Business.

Ripple holds a Bachelor of Science in Chemistry from Texas A&M University and an executive MBA from the University of Michigan’s Ross School of Business.