GLOBAL ISO 13485 MANUFACTURING FOOTPRINT Avient’s certified sites are located on three continents and offer manufacturing support, project transfer and back-up supply to reduce supply chain risk. COMPREHENSIVE REGULATORY TESTING AND DOCUMENTATION Raw materials tested to: • ISO 10993-1 and USP , (biological evaluation) • European Pharmacopeia 3.1.3/3.1.5 (polyolefin —materials used for the manufacture of containers) • USP (polyethylene—plastic materials of construction) • ICH Q3D (elemental impurities) We provide Drug Master File (Type III) documentation and other supporting regulatory declarations that are relevant for the application.

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Transitions between wall thickness should be gradual to reduce flow problems such as back fills and gas traps.

Microsoft Word - Terms and Conditions Finland _8 April 2014_.doc TERMS AND CONDITIONS These Terms and Conditions apply to the sale of Products by PolyOne Corporation and its subsidiaries. 1. All late payments shall bear an annual interest of one (1) month EURIBOR plus 8% accrued on a daily basis, notwithstanding any damages. GOVERNMENTAL CONSTRAINTS If a present or future law, governmental decree, order, regulation, or ruling under any existing or future legislation prevents Seller from increasing or revising the price as provided herein, or nullifies or reduces any price or price increase hereunder, upon written notice from one to the other Seller and Buyer will attempt to identify mutually agreeable changes to conform these Terms and Conditions with such law, decree, order, regulation, or ruling.

In fact, case studies have shown scrap rates can be reduced from 30% to less than 1%.

For coloring TPEs, GLS recommends that you use high screw speeds (100-200 rpm), high back pressure (100psi), and a higher degree of ramping of the temperatures in the barrel. Concentrate let-down ratios as low as 10-to-1 and as high as 100-to-1 are possible depending on the process and desired result. However, anything over a 25-to-1 ratio requires special attention and handling.

For coloring TPEs, GLS recommends that you use high screw speeds (100-200 rpm), high back pressure (100psi), and a higher degree of ramping of the temperatures in the barrel. Concentrate let-down ratios as low as 10-to-1 and as high as 100-to-1 are possible depending on the process and desired result. However, anything over a 25-to-1 ratio requires special attention and handling.

Clause 1, Clause 2, Clause 3, Clause 6, Clause 7; ii. The details for “Table 1: Parties” shall be set out in Appendix to Schedules 2(a), (b), and (c), Annex 1; b. Entering into this Addendum 1.